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Asthma continues to be a chronic illness affecting millions of children worldwide. In spite of veiy good controller medications now available, Status Asthmaticus is one of the most common diagnosis among children admitted to the Pediatric Intensive Care Units. There are also a veiy wide variety of therapeutic options available to the intensivist for treating an asthma exacerbation. Although in conditions of extremes, probably it is worth to utilize all the therapies possible, more often than not, a practitioner has to choose one vs the other. In view of potential side effects of all the therapies, it is valuable to understand the evidence behind them. in this brief review we have tried to summarize the options and the research behind them.