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Management and outcomes of advanced hemangioendothelioma at a medical oncology clinic in an Indian tertiary care center
oleh: Ghazal Tansir, Sameer Rastogi, Adarsh Barwad, Rajni Yadav, Shamim Ahmed Shamim, Ekta Dhamija, Rambha Pandey, Rakesh Garg, Shakti Shrivastava
Format: | Article |
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Diterbitkan: | Future Science Ltd 2022-12-01 |
Deskripsi
Aim: Hemangioendotheliomas (HEs) are malignant vascular tumors with sparse descriptions in literature owing to their rarity. Study design: Ours is a retrospective study among patients of advanced HEs registered between September 2015 and April 2021. Results: There were 13 patients with median age 34.6 (range: 4–69 years), male preponderance (69%) and predominant subtype of epithelioid HE (76.9%). Common primary sites were viscera (46.2%) and bone (30.8%). Tyrosine kinase inhibitors (TKIs) yielded objective responses in 30% patients whereas chemotherapy only produced disease stabilization in 7.7%. Conclusion: We recognize an aggressive subset of HEs with manifestations such as acute liver failure and splenic rupture. Currently no biomarkers predict the efficacy of TKIs over chemotherapy; however, TKIs showed promising outcomes in this series.