Organocatalytic asymmetric selenofunctionalization of tryptamine for the synthesis of hexahydropyrrolo[2,3-b]indole derivatives
oleh: Qiang Wei, Ya-Yi Wang, Yu-Liu Du, Liu-Zhu Gong
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2013-08-01 |
Deskripsi
A chiral phosphoric acid-catalyzed selenofunctionalization of tryptamine derivatives provides access to 3a-(phenylselenyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole derivatives in high yields and with synthetically useful levels of enantioselectivity (up to 89% ee).