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Objective: To study the characteristics and outcome of patients having postpartum Acute Kidney Injury requiring hemodialysis and factors associated with poor outcome. Study Design: Cross-sectional study. Place and Duration of Study: Department of Gynecology, Medicine and Nephrology, Pak Emirates Military Hospital, Rawalpindi and Combined Military Hospital Kharian Pakistan, Jun 2021 to Feb 2022. Methodology: Fifty patients diagnosed as having Acute Kidney Injury during post-partum period and requiring hemodialysis were included the study. They were managed and followed up by Nephrology team for three months and outcome was recorded as good or bad on the basis of response to treatment and clinical condition. Relevant socio-demographic factors associated with outcome in study participants were also recorded on a data collection proforma. Results:  Out of 50 patients with dialysis dependent Acute Kidney Injury, 25(50%) had normal vaginal delivery while 25(50%) had either cesarean or instrumental delivery. Mean age of the study participants was 33.45±6.732 years. 30(60%) patients had good outcome while 20(40%) patients had poor outcome. Statistical test revealed that post-partum hemorrhage and presence of gestational diabetes mellitus or hypertension had statistically significant relationship with poor outcome in patients suffering from dialysis dependent post-partum acute kidney injury (p-value<0.05). Conclusion: Significant number of patients with hemodialysis dependent post-partum acute kidney injury had good outcome at the end of three months. Patients with post-partum hemorrhage and presence of gestational diabetes mellitus or hypertension were more at risk of having poor outcome of acute kidney injury.