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Background and aims: Nephrotic syndrome is the most common manifestation of glomerular damage in children. Due to being a chronic disease as well as the need to continuing the provision cares to reduce the recurrence of disease, this research was aimed to determine the effect of continuous care model on parents’ knowledge and controlling symptoms and recurrence in children with nephrotic syndrome. Methods: This research is an experimental study which 66 children with nephrotic syndrome qualified for inclusion in the study, were randomly classified into 2 groups: Case and control. Data were collected by a researcher-designed questionnaire, and checklist for recording blood pressure, weight, blood lipids and the presence or absence of recurrence in children in the 2 groups before and after intervention. Continuous care model was carried out on test group for 6 months. Data were analyzed by SPSS software using descriptive statistics, Chi-square, and Independent t-test and McNamara tests. Results: The proportion of disease recurrence after the intervention in both case and control groups showed no significant difference (P=0.787), but mean of systolic blood pressure in both groups after the intervention showed significant differences (P=0.011). Also, the level of parentschr('39') knowledge ratio in both groups after the intervention showed significant differences (P=0.0001). Conclusion: According to the study results, it is suggested that children care needs with nephrotic syndrome will be met by using the implementation of continuous care model.