Death receptor 6 contributes to autoimmunity in lupus-prone mice
oleh: Daisuke Fujikura, Masahiro Ikesue, Tsutomu Endo, Satoko Chiba, Hideaki Higashi, Toshimitsu Uede
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-01-01 |
Deskripsi
Germinal centre (GC) reactions are driven by T follicular helper (Tfh) cells and their dysregulation can cause autoimmune disease. Here the authors show that the orphan receptor DR6 is a Tfh cell marker that binds syndecan-1 on GC B cells driving autoimmunity in lupus-prone mice.