PRMT5 is essential for B cell development and germinal center dynamics
oleh: Ludivine C. Litzler, Astrid Zahn, Alexandre P. Meli, Steven Hébert, Anne-Marie Patenaude, Stephen P. Methot, Adrien Sprumont, Thérence Bois, Daisuke Kitamura, Santiago Costantino, Irah L. King, Claudia L. Kleinman, Stéphane Richard, Javier M. Di Noia
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-01-01 |
Deskripsi
Protective antibody responses depend critically on proper B cell development and differentiation at multiple stages. Here the authors show that a protein arginine methyltransferase, Prmt5 uses multiples pathways to prevent death of immature B cells, yet modulates, in p53-independent manners, the survival and differentiation of mature B cells.