Research advance on telomere shortening and bone marrow failure diseases
oleh: GAO Xiao-yan, LIU Shu-chuan
| Format: | Article |
|---|---|
| Diterbitkan: | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2021-01-01 |
Deskripsi
Telomere shortening is an important pathogenesis of bone marrow failure diseases. As a therapeutic target, telomere may become a new research direction for bone marrow failure diseases. Telomere shortening is related to clinical acquired bone marrow failure diseases, including aplastic anemia, myelodysplastic syndrome and immune mechanism related pancytopenia. The relation between telomere shortening and some inherited bone marrow failure diseases, including dyskeratosis congenita, fanconi anemia is also referred.