Quantitative modelling of amino acid transport and homeostasis in mammalian cells
oleh: Gregory Gauthier-Coles, Jade Vennitti, Zhiduo Zhang, William C. Comb, Shuran Xing, Kiran Javed, Angelika Bröer, Stefan Bröer
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-09-01 |
Deskripsi
Cytosolic amino acid concentrations are carefully maintained, but how homeostasis occurs is unclear. Here, the authors show that amino acid transporters primarily determine intracellular amino acid levels and develop a model that predicts a perturbation response similar to experimental data.