Quantitative modelling of amino acid transport and homeostasis in mammalian cells

oleh: Gregory Gauthier-Coles, Jade Vennitti, Zhiduo Zhang, William C. Comb, Shuran Xing, Kiran Javed, Angelika Bröer, Stefan Bröer

Format: Article
Diterbitkan: Nature Portfolio 2021-09-01

Deskripsi

Cytosolic amino acid concentrations are carefully maintained, but how homeostasis occurs is unclear. Here, the authors show that amino acid transporters primarily determine intracellular amino acid levels and develop a model that predicts a perturbation response similar to experimental data.