Metagenomic Investigation of Torque Teno Mini Virus-SH in Hematological Patients
oleh: Antonin Bal, Antonin Bal, Antonin Bal, Guy Oriol, Laurence Josset, Laurence Josset, Laurence Generenaz, Clémentine Sarkozy, Pierre Sesques, Gilles Salles, Florence Morfin, Florence Morfin, Bruno Lina, Bruno Lina, Jérémie Becker, Frédéric Reynier, François Mallet, Alexandre Pachot, Valérie Cheynet, Karen Brengel-Pesce, Sophie Trouillet-Assant, Sophie Trouillet-Assant
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2019-09-01 |
Deskripsi
A new member of Anelloviridae, named torque teno mini virus (TTMV)-SH, was recently identified in the serum of three Hodgkin’s lymphoma patients suggesting that TTMV-SH may be associated with this type of hematological malignancy. We investigated by metagenomic analysis the presence of TTMV-SH-related viruses in plasma samples (n = 323) collected from patients with various hematological malignancies (multiple myeloma (MM, n = 256), non-Hodgkin’s lymphoma (NHL, n = 20), acute myeloid leukemia (n = 10)) and from healthy donors (n = 37). TTMV-SH-related strains were identified in 24 samples corresponding to four MM and one NHL patients. Phylogenic analysis revealed that the 24 isolates were close to the TTMV-SH strains previously identified, sharing 79.6–86.7% ORF1 nucleotide sequence identity. These results suggest that TTMV-SH-related viruses might be found in hematological diseases other than Hodgkin’s lymphoma. Due to the high genetic variability within Anelloviridae species, the association between a particular medical condition and a new genotype should be interpreted with caution.