Find in Library

<p>Abstract</p> <p>Background</p> <p>The lectin-like oxidized LDL receptor LOX-1 (encoded by <it>OLR1</it>) is believed to play a key role in atherogenesis and some reports suggest an association of <it>OLR1 </it>polymorphisms with myocardial infarction (MI). We tested whether single nucleotide polymorphisms (SNPs) in <it>OLR1 </it>are associated with clinically significant CAD in the <it>A</it>therosclerotic <it>D</it>isease, <it>VA</it>scular FuNction, & Geneti <it>C E</it>pidemiology (ADVANCE) study.</p> <p>Methods</p> <p>ADVANCE is a population-based case-control study of subjects receiving care within Kaiser Permanente of Northern California including a subset of participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study. We first resequenced the promoter, exonic, and splice site regions of <it>OLR1 </it>and then genotyped four single nucleotide polymorphisms (SNPs), including a non-synonymous SNP (rs11053646, Lys167Asn) as well as an intronic SNP (rs3736232) previously associated with CAD.</p> <p>Results</p> <p>In 1,809 cases with clinical CAD and 1,734 controls, the minor allele of the coding SNP was nominally associated with a lower odds ratio (OR) of CAD across all ethnic groups studied (minimally adjusted OR 0.8, P = 0.007; fully adjusted OR 0.8, P = 0.01). The intronic SNP was nominally associated with an increased risk of CAD (minimally adjusted OR 1.12, p = 0.03; fully adjusted OR 1.13, P = 0.03). However, these associations were not replicated in over 13,200 individuals (including 1,470 cases) in the Atherosclerosis Risk in Communities (ARIC) study.</p> <p>Conclusion</p> <p>Our results do not support the presence of an association between selected common SNPs in <it>OLR1 </it>and the risk of clinical CAD.</p>