miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease
oleh: Kai Zheng, Fan Hu, Yang Zhou, Juan Zhang, Jie Zheng, Chuan Lai, Wan Xiong, Ke Cui, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Jian-Guo Chen, Heng-Ye Man, Dan Liu, Youming Lu, Ling-Qiang Zhu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-03-01 |
Deskripsi
Several micro RNAs have been shown to be deregulated in brain tissue or sera from individuals with Alzheimer’s disease and in AD mouse models. The authors show that miR-135a-5p is downregulated in excitatory pyramidal neurons from AD mice and that dysfunction of miR-135a-5p/Rock2/Add1 results in memory/synaptic disorder in AD.