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Strictinin isolated from Pu’er tea was demonstrated to inhibit pancreatic lipase in vitro. In an olive oil tolerance test, the administration of strictinin (100 mg/kg) significantly reduced the blood triglyceride level and increased the fecal oil content of C57BL6 mice. In a long-term animal study, the body weight gained via high-fat diet was significantly reduced in the mice supplemented with strictinin of 130 mg/kg. Further analysis showed that weight of epididymal fat, but not that of liver or muscle, increased in mice fed with high-fat diet, and the increase of fat was reduced in the mice supplemented with strictinin. Correspondingly, sizes of adipocytes in epididymis were substantially enlarged in mice fed with high-fat diet, and the enlargement of adipocytes was decreased when strictinin was supplemented. Levels of blood triglyceride, cholesterol and glucose were elevated in mice fed with high-fat diet, and these elevated levels were reduced when strictinin was supplemented.