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This ecological study investigated the association between social and environmental inequities and dental caries among indigenous people in Brazil. Dental caries data were gathered from articles identified from electronic databases for the period between 2000 and 2007. Independent variables were obtained from the census of Health Information System for Sanitation Indigenous Populations. Multiple linear regression analysis was conducted to test the association between social and environmental characteristics and dental caries (DMFT index) according to the age group. Results were analyzed for 48 indigenous peoples from 19 selected studies. The occurrence of dental caries in particular age groups was inversely associated with the location of villages outside the Amazon region (12, 15 - 19, and 20 - 34 years), availability of electricity (15 - 19 and 20 - 34 years) and proportion of households covered with straw/thatch (20 - 34 years). The presence of schools was statistically associated with higher DMFT averages (15 - 19 and 20 - 34 years). It can be concluded that aspects of location and existing infrastructure in indigenous communities, which are linked to the availability of oral health services, are associated with the occurrence of dental caries in indigenous populations in Brazil.