Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2
oleh: Jun Zhang, Jennifer F. Pinello, Ignacio Fernández, Eduard Baquero, Juliette Fedry, Félix A. Rey, William J. Snell
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-07-01 |
Deskripsi
HAP2 is essential for gamete fusion during fertilization and is conserved among eukaryotes. Here the authors show that species-specific adhesion between Chlamydomonas plus and minus gametes initiates HAP2 to undergo a fusogenic conformational change into homotrimers via a molecular mechanism akin to that of enveloped viruses.