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Antibiotics have played a pivotal role in modern healthcare. They have been instrumental in treatment and prevention of infections in various clinical settings, but effectiveness of antibiotics is decreasing which is largely because of development of antibiotic resistance. The development of generations of antibiotic -resistant microbes and their widespread distribution in microbes throughout the environment is because of many years of unremitting selection pressure from human and animal applications of antibiotics. This is a manmade situation, and with the help of natural processes, superimposed on nature. Until recently, the effects of antimicrobial resistance were not felt much as there has been a continuous stream of newer antibiotics. However, over the past 2 decades, there has been dearth of new antibiotics from pharmaceutical companies leading to inability to fight these MDR organisms. This marked increase in antimicrobial resistance among common bacterial pathogens is now threatening this therapeutic accomplishment, jeopardizing the successful outcomes of critically ill patients and is cause of severe infections, complications, longer hospital stays and increased mortality. In fact, the World Health Organization has named antibiotic resistance as one of the three most important public health threats of the 21st century.