PPARα−ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis
oleh: Sujeong Park, In-Jeoung Baek, Ji Hyun Ryu, Churl-Hong Chun, Eun-Jung Jin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-01-01 |
Deskripsi
Increasing evidence suggested that dysregulation in lipid metabolism is linked to OA pathogenesis, but the underlying regulatory mechanism is not well understood. Here, the authors show that PPARα-ACOT12 signalling regulates cartilage homeostasis by regulating de novo lipogenesis in mice.