Comparison of safety and efficacy of convalescent plasma with fresh frozen plasma in severe covid-19 patients
oleh: MEENU BAJPAI, ASHISH MAHESHWARI, SURESH KUMAR, KARAN CHHABRA, PRATIBHA KALE, ASHAD NARAYANAN, AMITA GUPTA, EKTA GUPTA, NIRUPAMA TREHANPATI, RESHU AGARWAL, KAMINI GUPTA, ANKIT BHARDWAJ, MOJAHIDUL ISLAM, RAVINDER SINGH, PUSHPA YADAV, GURESH KUMAR, SHIV K. SARIN
| Format: | Article |
|---|---|
| Diterbitkan: | Academia Brasileira de Ciências 2022-09-01 |
Deskripsi
Abstract background: Role of Convalescent plasma (COPLA) to treat severe COVID-19 is under investigation. We compared efficacy and safety of COPLA with fresh frozen plasma (FFP) in severe COVID-19 patients. Methods: One group received COPLA with standard medical care (n = 14), and another group received random donor FFP, as control with standard medical care (n = 15) in severe COVID-19 disease. Results: The proportion of patients free of ventilation at day seven were 78.5% in COPLA group, and 93.3 % in control group were not significant (p= 0.258). However, improved respiratory rate, O2 saturation, SOFA score, and Ct value were observed in the COPLA group. No serious adverse events were noticed by plasma transfusion in both groups.