The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer
oleh: Derek J. Erstad, Andrew M. Tager, Yujin Hoshida, Bryan C. Fuchs
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2017-05-01 |
Deskripsi
Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals, identifying ATX-LPA signaling as a novel chemoprevention strategy for cirrhosis and HCC.