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Celiac disease (CD) is an autoimmune disease with high incidence of multi organ involvement; particularly, Gastrointestinal manifestations and a redoubled risk of malignancies. Here we tend to report a case of CD , reaction anemia (AIHA). who presented to us with history of abdominal pain fever and nausea and vomiting .her examination finding was anemia and spelenomegaly her laboratory tests showed increase liver enzymes and macrocytosis anemia with positive coombs without decrease in hemoglobin and high retic cell .Poly autoimmunity needs comprehensive analysis. , AIHA and CD were diagnosed throughout the admission upon in depth work-up. Similarly, alternative reaction etiologies,All diseases were treated with strict adherence to a diet (GFD) and cortico steroid therapy. This was a rare case a case of celiac presenting with such a good array of signs and symptoms has seldom been reportable within the literature and also the management of this patient was distinctive and difficult