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<!--[if gte mso 9]><xml> <o:OfficeDocumentSettings> <o:AllowPNG /> <o:PixelsPerInch>72</o:PixelsPerInch> <o:TargetScreenSize>1024x768</o:TargetScreenSize> </o:OfficeDocumentSettings> </xml><![endif]--> <p class="MsoNormal" style="text-align: justify;"><span style="font-size: 10.0pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; color: #141413; mso-no-proof: no;" lang="EN-US">The rind of pomegranate fruit (<em>Granati fructus </em>cortex) composed of antibacterial compounds such as alkaloid, flavonoid and tannin. <strong>Objective: </strong>To evaluate the bacterial effect of <em>Granati fructus </em>cortex extract against <em>Streptococcus mutans. </em><strong>Methods: </strong>The study was laboratory experimental. The inhibition test was performed by agar diffusion method on MHA medium. <strong>Results: </strong>It showed the bacterial property of <em>Granati fructus </em>cortex on various concentration. The highest extract concentration of 30% extract has the largest of inhibition zones (15.4mm). The results showed a difference in the size of inhibition zones related to different extract concentrations. <strong>Conclusion: </strong>This study confirmed the antibacterial effect of <em>Granati fructus </em>cortex on the growth of <em>Streptococcus mutans.</em></span></p><p class="MsoNormal" style="text-align: justify;"><span style="font-size: 10.0pt; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; color: #141413; mso-no-proof: no;" lang="EN-US">DOI: </span>10.14693/jdi.v20i1.126</p>