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Multiphase flow with self-driven particles is ubiquitous and complex. Exploring the flow properties has both important academic meaning and engineering value. This review emphasizes some recent studies on multiphase flow with self-driven particles: the hydrodynamic interactions between self-propelled/self-rotary particles and passive particles; the aggregation, phase separation and sedimentation of squirmers; the influence of rheological properties on its motion; and the kinematic characteristics of axisymmetric squirmers. Finally, some open problems, challenges, and future directions are highlighted.