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(–)-Epigallocatechin-3-<i>O</i>-gallate (EGCG), the most abundant component of catechins in tea (<i>Camellia sinensis</i> (L.) O. Kuntze), plays a role against viruses through inhibiting virus invasiveness, restraining gene expression and replication. In this paper, the antiviral effects of EGCG on various viruses, including DNA virus, RNA virus, coronavirus, enterovirus and arbovirus, were reviewed. Meanwhile, the antiviral effects of the EGCG <i>epi</i>-isomer counterpart (+)-gallocatechin-3-<i>O</i>-gallate (GCG) were also discussed.