New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis
oleh: Jieli Shen, Daisy F. Rangel, Dat Ha, Amy S. Lee
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2017-11-01 |
Deskripsi
Metaplasia is emerging as a key process in tumorigenesis. We discovered that 2 essential endoplasmic reticulum (ER) chaperones, 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) have a role in metaplasia. Grp78 haploinsufficiency in the mouse pancreas impairs acinar-to-ductal metaplasia, whereas in the uterus, Grp94 loss induces squamous cell metaplasia; both resulting in tumor suppression.