Ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/CCu catalysis

oleh: Sallagundla Bhavani, Dandela Rambabu, Mandava Venkata Basaveswara Rao, Manojit Pal

Format: Article
Diterbitkan: Elsevier 2019-12-01

Deskripsi

A convenient synthetic method has been developed for accessing 2,6-dialkynyl-3,5-dichloropyridine derivatives in acceptable to good yields. The methodology involved ultrasound assisted site-selective alkynylation of 2,3,5,6-tetrachloropyridines under Pd/CCu catalysis. A variety of terminal alkynes were employed in this CC coupling reaction to afford the corresponding 2,6-dialkynyl-3,5-dichloropyridine derivatives. Keywords: Pyridine, Alkynes, Pd/C, Ultrasound