The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3
oleh: Hui Song, Bingyu Liu, Wanwan Huai, Zhongxia Yu, Wenwen Wang, Jing Zhao, Lihui Han, Guosheng Jiang, Lining Zhang, Chengjiang Gao, Wei Zhao
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-12-01 |
Deskripsi
The NLRP3 inflammasome controls the response of the host to pathogens; precise regulation is required to limit autoimmune diseases. Here, the authors identify the E3 ligase TRIM31 that aids the ubiquitin-mediated proteasomal degradation of NLRP3, which may be a therapeutic target for alleviating disease.