Biomimetically inspired asymmetric total synthesis of (+)-19-dehydroxyl arisandilactone A
oleh: Yi-Xin Han, Yan-Long Jiang, Yong Li, Hai-Xin Yu, Bing-Qi Tong, Zhe Niu, Shi-Jie Zhou, Song Liu, Yu Lan, Jia-Hua Chen, Zhen Yang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-01-01 |
Deskripsi
Arisandilactone A is a natural product with a complex oxa-bridged tricyclic carbon core, making it a challenging target in total synthesis. Here the authors report an asymmetric total synthesis of its 19-dehydroxy derivative, with homo-Michael and tandem retro-Michael/Michael reactions as key steps.