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The burden of breast cancer is increasing fast in low resource areas of China. Uultrasonography is widely used as a primary method for breast cancer screening in China. However, effective ultrasonography is highly dependent on the operators’ professional skills and long-term efficacy of the ultrasonography screening needs to be evaluated with high-quality prospective cohort studies. The development of automated breast volume scanner and artificial intelligence technology is expected to promote the performance of breast cancer screening in regions with low health resources; the efficacy of the two means in breast cancer screening needs to be further verified and the implementation of the new process needs to be explored. Given the economic and medical heterogeneity across different regions of China, it is necessary to explore screening strategies suitable for different situations, especially for regions with low health resources.