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Calanone, is a coumarin derivate which was isolated from the stem bark of Calophyllum biflorum.To know the effect of calanone on the in vivo growth of transplantable C3H mammary tumor cells, C3H mice were used which were divided into : one group of untreated control, one group of solvent control (injected with 0,1 mL PEG 400) and four treated groups, each of which were injected subcutaneously near the tumor with 0,1 mL of 1 mg/mL, 2 mg/mL, 4 mg/mL, and 8 mg/mL of calanone in PEG 400 solvent respectively. The injections were given three times a week, for four weeks. By using Friedman test, for non parametric statistical analysis of the weekly observed tumor volume, it was shown that there was a significant decrease in the tumor growth of the group treated with calanone solution of 4 mg/mL dosage, compared to the control or other groups.