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Background. <i>Porphyromonas gingivalis</i> (<i>P. gingivalis</i>) has always been one of the leading causes of periodontal disease, and antibiotics are commonly used to control it. Numerous side effects of synthetic drugs, as well as the spread of drug resistance, have led to a tendency toward using natural antimicrobials, such as curcumin. The present study aimed to prepare and physicochemically characterize curcumin-loaded silica nanoparticles and to detect their antimicrobial effects on <i>P. gingivalis</i>. Methods. Curcumin-loaded silica nanoparticles were prepared using the chemical precipitation method and then were characterized using conventional methods (properties such as the particle size, drug loading percentage, and release pattern). <i>P. gingivalis</i> was isolated from one patient with chronic periodontal diseases. The patient’s gingival crevice fluid was sampled using sterile filter paper and was transferred to the microbiology laboratory in less than 30 min. The disk diffusion method was used to determine the sensitivity of clinically isolated <i>P. gingivalis</i> to curcumin-loaded silica nanoparticles. SPSS software, version 20, was used to compare the data between groups with a <i>p</i> value of <0.05 as the level of significance. Then, one-way ANOVA testing was utilized to compare the groups. Results. The curcumin-loaded silica nanoparticles showed a nanometric size and a drug loading percentage of 68% for curcumin. The nanoparticles had a mesoporous structure and rod-shaped morphology. They showed a relatively rapid release pattern in the first 5 days. The release of the drug from the nanoparticles continued slowly until the 45th day. The results of <i>in vitro</i> antimicrobial tests showed that <i>P. gingivalis</i> was sensitive to the curcumin-loaded silica nanoparticles at concentrations of 50, 25, 12.5, and 6.25 µg/mL. One-way ANOVA showed that there was a significant difference between the mean growth inhibition zone, and the concentration of 50 µg/mL showed the highest inhibition zone (<i>p</i> ≤ 0.05). Conclusion. Based on the obtained results, it can be concluded that the local nanocurcumin application for periodontal disease and implant-related infections can be considered a promising method for the near future in dentistry.