Echinocandins as Biotechnological Tools for Treating <i>Candida auris</i> Infections

por: Elizabete de Souza Cândido, Flávia Affonseca, Marlon Henrique Cardoso, Octavio Luiz Franco

Formato: Article
Publicado: MDPI AG 2020-09-01

Descripción

<i>Candida auris</i> has been reported in the past few years as an invasive fungal pathogen of high interest. Its recent emergence in healthcare-associated infections triggered the efforts of researchers worldwide, seeking additional alternatives to the use of traditional antifungals such as azoles. Lipopeptides, specially the echinocandins, have been reported as an effective approach to control pathogenic fungi. However, despite its efficiency against <i>C. auris</i>, some isolates presented echinocandin resistance. Thus, therapies focused on echinocandins’ synergism with other antifungal drugs were widely explored, representing a novel possibility for the treatment of <i>C. auris</i> infections.