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Acute connective tissue (CT) is an actual problem in modern surgery. Its share ranges from 3.3 to 10 % of all acute surgical diseases. Restoration of work capacity of patients occurs only in 45–50 % of cases, and postoperative lethality is 11.6–23.8 %. The aim of the study – to examine the dynamics of blood levels of immunoglobulins under the influence of complex treatment of patients with acute adhesive intestinal obstruction. Materials and Methods. We examined 182 patients with acute adhesive intestinal obstruction. 152 (83.5 %) patients were operated on and 30 (16.5 %) patients were treated conservatively. Also, we examined additional control group of healthy individuals. In patients we determined the content of Ig A, Ig M, Ig G by enzyme immunoassay, using reagents of the company "Granum" (Ukraine). Results and Discussion. In the context of acute adhesive intestinal obstruction in the stage of decompensation during hospitalization in patients we marked hyperactivity of humoral immunity, which is manifested by a significant increase in the content of immunoglobulin classes A, M, G with their gradual reduction to 5 days of postoperative period. Application in complex intensive therapy of the developed method of treatment leads to more rapid improvement in humoral immunity, as evidenced by significantly lower contents of the investigated immunoglobulin within 5 days of the postoperative period in comparison with the traditional treatment.