Altered developmental programs and oriented cell divisions lead to bulky bones during salamander limb regeneration
oleh: Marketa Kaucka, Alberto Joven Araus, Marketa Tesarova, Joshua D. Currie, Johan Boström, Michaela Kavkova, Julian Petersen, Zeyu Yao, Anass Bouchnita, Andreas Hellander, Tomas Zikmund, Ahmed Elewa, Phillip T. Newton, Ji-Feng Fei, Andrei S. Chagin, Kaj Fried, Elly M. Tanaka, Jozef Kaiser, András Simon, Igor Adameyko
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
Normal limb development relies on synchronized formation of cartilage and bone. Here, the authors show that in salamander limb regeneration these processes are decoupled: ossification occurs after the final size of regenerating cartilage is reached, allowing fast regeneration and leading to bulky bones.