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Three sets of priority cells for mammal conservation in Mexico were identified using distributional data. A complementarity approach was implemented through linear integer programming. The minimum set of sites required for the representation of each mammal species varied between 38 (5.4%) grid cells for at least one occurrence, 110 (15.6%) grid cells for at least three occurrences, and 173 (24.5%) grid cells for at least five occurrences. The complementary analyses mainly highlighted three regions of particular concern for mammal conservation in Mexico: (i) the trans-Mexican Volcanic Belt and natural provinces of the Pacific Coast, (ii) Sierra Madre del Sur and the Highlands of Chiapas, and (iii) the northern portion of the Sierra Madre Occidental. The results reported here did not indicate absolute priority locations for conservation activities, but rather identified locations warranting further investigation at finer resolutions more appropriate to such activity