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Cancer is one of the problems of human society that threatens human health. Since anti-cancer drugs have multiple side effects, identification of the biological processes and the protozoan antigens leads to the introduction of suitable candidates. In this experimental study, the effect of cisplatinum and Toxoplasma gondii and Leishmania major peptic ulcers on isolated, susceptible (A2780-CP) and susceptible (A2780) and resistant strains (A2780) to Cysplatinum was evaluated individually and combined. MTT test was used to determine the cell survival and trypan blue coloring was used to determine the cell proliferation and cell count. Data were calculated using SPSS software and GraphPad prism5 software. The amount of cell proliferation in the two experimental groups was significantly lower than the control group. The highest reduction in proliferation and dead cells was observed in two experimental groups in the group treated with Leishmania major peptic ulcer extract with cisplatin. Parasitic extracts of Toxoplasma gondii and Leishmania Major can have significant lethal effects on both cancer cell lines due to their complex excretion / secretion antigens.