Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures
oleh: Meihua Wang, Rui Li, Bo Shu, Xuping Jing, Han-Qing Ye, Peng Gong
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-05-01 |
Deskripsi
During translocation by viral RNA-dependent RNA polymerases (RdRP), the template-product RNA duplex moves in an asymmetric manner. Here the authors describe several crystal structures of RdRP translocations intermediates that, along with enzymological data, provide a comprehensive view of RdRP translocation.