Brainstem Associated Somatosensory Evoked Potentials and Response to Vagus Nerve Stimulation: An Investigation of the Vagus Afferent Network
oleh: Hrishikesh Suresh, Hrishikesh Suresh, Hrishikesh Suresh, Karim Mithani, Karim Mithani, Karanbir Brar, Han Yan, Han Yan, Han Yan, Samuel Strantzas, Mike Vandenberk, Roy Sharma, Ivanna Yau, Christina Go, Elizabeth Pang, Elizabeth Pang, Elizabeth Kerr, Elizabeth Kerr, Ayako Ochi, Hiroshi Otsubo, Puneet Jain, Elizabeth Donner, O. Carter Snead, O. Carter Snead, O. Carter Snead, George M. Ibrahim, George M. Ibrahim, George M. Ibrahim, George M. Ibrahim
| Format: | Article |
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| Diterbitkan: | Frontiers Media S.A. 2022-02-01 |
Deskripsi
Despite decades of clinical usage, selection of patients with drug resistant epilepsy who are most likely to benefit from vagus nerve stimulation (VNS) remains a challenge. The mechanism of action of VNS is dependent upon afferent brainstem circuitry, which comprises a critical component of the Vagus Afferent Network (VagAN). To evaluate the association between brainstem afferent circuitry and seizure response, we retrospectively collected intraoperative data from sub-cortical recordings of somatosensory evoked potentials (SSEP) in 7 children with focal drug resistant epilepsy who had failed epilepsy surgery and subsequently underwent VNS. Using multivariate linear regression, we demonstrate a robust negative association between SSEP amplitude (p < 0.01), and seizure reduction. There was no association between SSEP latency and seizure outcomes. Our findings provide novel insights into the mechanism of VNS and inform our understanding of the importance of brainstem afferent circuitry within the VagAN for seizure responsiveness following VNS.