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Background: One of the important goals of therapeutic interventions is to control obesity and vitamin D deficiency, which are associated with the occurrence of cardiovascular disease, metabolic disorders and increased homocysteine. In this study, the effect of high-intensity interval resistance training (HIIRT) and vitamin D on homocysteine and total antioxidant capacity (TAC) ​​levels in overweight women with vitamin D deficiency was investigated. Materials and Methods: In this clinical trial study, overweight women with vitamin D deficiency were investigated. The subjects were randomly divided into four groups of 13 (control, exercise, vitamin D and exercise+vitamin D). The exercise groups performed HIIRT with an intensity of 80% of one maximum repetition, and the vitamin D groups consumed vitamin D once a week. The collected data were analyzed using one-way analysis of variance and paired t-tests. Results: After 8 weeks of research interventions, homocysteine level decreased and TAC significantly increased in the experimental groups (P<0.001). In addition, combined intervention was associated with more changes in homocysteine and TAC levels compared to HIIRT and vitamin D intervention (P<0.001), but HIIRT and vitamin D had a similar effect on the changes of these variables (P>0.05). Conclusion: It seems that part of the optimal effects of HIIRT and vitamin D consumption in the health development of overweight women with vitamin D deficiency can be induced by increasing TAC and decreasing homocysteine.