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The anaesthetic study was conducted in 12 female dogs of different breeds, subjected to elective surgical procedures (oophorectomies). They were randomly divided into two groups each consisting of six animals and were numbered serially from 1 to 6. Animals of group 1 were premedicated by intramuscular administration of glycopyrrolate (0.011 mg/kg body weight) followed by xylazine (1.0 mg/kg body weight) at 15 minutes interval. !n animals of Group ll, ten minutes later midazolam (0.3 mg/kg body weight) was also administered intravenously. Fifteen minutes, after premedication in both the groups ketamine hydrochloride (10 mg/kg body weight) was administered intramuscularly for the induction and maintenance of general anaesthesia. !n animals premedicated with midazolam, endotracheal intubation was easy and the degree of muscle relaxation during anaesthesia was good. The depth of anaesthesia achieved without midazolam premedication was found not satisfactory for major surgical procedures like laparotomy. But it was satisfactory in midazolam-premedicated animals. All the animals of both groups had an uneventful recovery, though the dogs showed varying degrees of dullness, which lasted for two to six hours