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This essay discusses the affect of a group of well-known buildings and one project from antiquity to the recent past: Pantheon, Rome; Hagia Sophia, Istanbul; Leon Battista Alberti’s Sant’Andrea, Mantua; Etienne-Louis Boullée’s Project for a Newton Cenotaph; Louis I. Kahn’s Salk Institute for Biological Studies, La Jolla and Frank O. Gehry’s Guggenheim Museum, Bilbao. Despite the disparities in time, at least two of the works considered have characteristics in common, while others have more.