Oral microbial extracellular DNA initiates periodontitis through gingival degradation by fibroblast-derived cathepsin K in mice
oleh: Takeru Kondo, Hiroko Okawa, Akishige Hokugo, Bhumika Shokeen, Oskar Sundberg, Yiying Zheng, Charles E. McKenna, Renate Lux, Ichiro Nishimura
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-09-01 |
Deskripsi
A highly sensitive imaging probe shows that oral microbial extracellular DNA triggers early activity of Ctsk in gingival fibroblasts, initiating periodontitis in mice.