Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4
oleh: Julio Gomez-Rodriguez, Françoise Meylan, Robin Handon, Erika T. Hayes, Stacie M. Anderson, Martha R. Kirby, Richard M. Siegel, Pamela L. Schwartzberg
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-03-01 |
Deskripsi
The Tec family tyrosine kinase, Itk, is a component of the T-cell receptor essential for optimal Th2 responses in vivo. Here the authors show in human cells and mouse models that Itk is also needed for the production of IL-9, an important contributor to allergic asthma.