Germline determinants of humoral immune response to HPV-16 protect against oropharyngeal cancer
oleh: Aida Ferreiro-Iglesias, James D. McKay, Nicole Brenner, Shama Virani, Corina Lesseur, Valerie Gaborieau, Andy R. Ness, Rayjean J. Hung, Geoffrey Liu, Brenda Diergaarde, Andrew F. Olshan, Neil Hayes, Mark C. Weissler, Lea Schroeder, Noemi Bender, Michael Pawlita, Steve Thomas, Miranda Pring, Tom Dudding, Beatriz Kanterewicz, Robert Ferris, Sera Thomas, Yonathan Brhane, Virginia Díez-Obrero, Maja Milojevic, Karl Smith-Byrne, Daniela Mariosa, Mattias J. Johansson, Rolando Herrero, Stefania Boccia, Gabriella Cadoni, Martin Lacko, Ivana Holcátová, Wolfgang Ahrens, Pagona Lagiou, Areti Lagiou, Jerry Polesel, Lorenzo Simonato, Franco Merletti, Claire M. Healy, Bo T. Hansen, Mari Nygård, David I. Conway, Sylvia Wright, Tatiana V. Macfarlane, Max Robinson, Laia Alemany, Antonio Agudo, Ariana Znaor, Christopher I. Amos, Tim Waterboer, Paul Brennan
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2021-10-01 |
Deskripsi
Genetic susceptibility loci for oropharyngeal cancer have been reported but these studies have not always examined human papillomavirus (HPV) status. Here, the authors perform genome-wide analysis taking into account HPV16 serology status and report two independent loci in the HLA region, suggesting the protective role of HLA variants against HPV infection.