DUB1 suppresses Hippo signaling by modulating TAZ protein expression in gastric cancer
oleh: Dehai Wang, Zhongbo Li, Xin Li, Cheng Yan, Huijie Yang, Ting Zhuang, Xiao Wang, Yifeng Zang, Ziping Liu, Tianshi Wang, Rixia Jiang, Peng Su, Jian Zhu, Yinlu Ding
| Format: | Article |
|---|---|
| Diterbitkan: | BMC 2022-07-01 |
Deskripsi
Highlights 1. DUB1 is an important modulator of Hippo signaling in gastric cancer. 2. DUB1 expression is elevated in human gastric cancer samples and correlates with poor survival in gastric cancer. 3. DUB1 facilitates gastric cancer progression via the Hippo/TAZ axis. 4. DUB1 associates with TAZ and directly inhibits YAP polyubiquitination and degradation.