Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells
oleh: Xingrong Lai, Xingrong Lai, Yanhua Sun, Xuedi Zhang, Xuedi Zhang, Dan Wang, Jialing Wang, Jialing Wang, Haihua Wang, Haihua Wang, Yao Zhao, Yao Zhao, Xinling Liu, Xinling Liu, Xin Xu, Xin Xu, Haoran Song, Wenjia Ping, Yanli Sun, Yanli Sun, Zhenbo Hu, Zhenbo Hu
| Format: | Article |
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| Diterbitkan: | Frontiers Media S.A. 2022-05-01 |
Deskripsi
Acute myeloid leukemia (AML) is one of the malignant hematological cancers with high mortality. Finding a more effective and readily available treatment is of the utmost importance. Here, we aimed to identify the anti-leukemia effect of a natural small molecule compound honokiol on a panel of AML cell lines, including THP-1, U-937, and SKM-1, and explored honokiol’s potential biological pathways and mechanisms. The results showed that honokiol decreased the viability of the targeted AML cells, induced their cell cycle arrest at G0/G1 phase, and inhibited their colony-formation capacity. Honokiol also triggers a noncanonical ferroptosis pathway in THP-1 and U-937 cells by upregulating the level of intracellular lipid peroxide and HMOX1 significantly. Subsequent studies verified that HMOX1 was a critical target in honokiol-induced ferroptosis. These results reveal that honokiol is an effective anti-leukemia agent in AML cell lines and may be a potential ferroptosis activator in AML.