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<b>Aim:</b> This study was conducted to evaluate the comparative efficacies of two different commercial products containing nitroxynil against liver fluke infestation for a period of 28 days by using 18 cattle.<p> <b>Materials and Methods:</b> Eighteen cattle were divided into 3 groups (A, B and C) where each group consisted of six cattle. Product A and Product B were injected subcutaneously to the cattle in group A and B, respectively. Cattle in group C were kept as infected control group without giving any treatment.<p> <b>Results:</b> A significant (P<0.01) reduction of egg per gram (EPG) count was found on 3^rd, 7^th, 14^th and 28th days of treated cattle of group A and B, respectively. The EPG count of control group were significantly (P<0.01) increased 7 day onwards up to experimental period. Reduction of mean EPG on 3rd, 7th, 14th and 28th day after treatment in group A and B were 83.9%-80.8%, 81.7%-80.7, 78.1%-77.0% and 73.7%-61.2%, respectively, whereas in control group the mean EPG were 6.7%, 9.2%, 21.4% and 30.9%, respectively. The body weight was increased significantly (P<0.01) after treatments in group A and B, respectively except untreated control group C.<p> <b>Conclusions:</b> This result may indicate that two commercial products contain nitroxynil have similar efficacies against fascioliasis in cattle.