Samarium(II) folding cascades involving hydrogen atom transfer for the synthesis of complex polycycles
oleh: Mateusz P. Plesniak, Monserrat H. Garduño-Castro, Philipp Lenz, Xavier Just-Baringo, David J. Procter
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-11-01 |
Deskripsi
Diversity-oriented synthesis is a valuable strategy to construct complex molecules of medicinal interest. Here, the authors show a folding cascade strategy to convert linear substrates into polycyclic compounds with multiple stereocentres by combining the reductive chemistry of SmI2 with 1,5-hydrogen atom transfer.