Switching at the ribosome: riboswitches need rProteins as modulators to regulate translation
oleh: Vanessa de Jesus, Nusrat S. Qureshi, Sven Warhaut, Jasleen K. Bains, Marina S. Dietz, Mike Heilemann, Harald Schwalbe, Boris Fürtig
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-08-01 |
Deskripsi
Translational regulation by riboswitches is an important mechanism for the modulation of gene expression in bacteria. Here the authors show that the ligand-induced allosteric switch in the adenine-sensing riboswitch from V. vulnificus is insufficient and leads only to a partial opening of the ribosome binding site and requires interaction with 30S-bound ribosomal protein S1, which acts as an RNA chaperone.