Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways
oleh: Milton Guilherme Forestieri Fernandes, Julia Xiao Xuan Luo, Qiao-Ling Cui, Kelly Perlman, Florian Pernin, Moein Yaqubi, Jeffery A. Hall, Roy Dudley, Myriam Srour, Charles P. Couturier, Kevin Petrecca, Catherine Larochelle, Luke M. Healy, Jo Anne Stratton, Timothy E. Kennedy, Jack P. Antel
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-01-01 |
Deskripsi
Milton Fernandes et al. combine single cell RNA-sequencing and functional assays to show that human oligodendrocytes exhibit an age-dependent resistance to apoptosis. Their findings have important implications for the pathology and treatment of myelination disorders like multiple sclerosis.