Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses
oleh: Yuhang Jiang, Cuifeng Li, Qian Wu, Peng An, Laiquan Huang, Jia Wang, Chen Chen, Xi Chen, Fan Zhang, Li Ma, Sanhong Liu, Hanqing He, Shuyun Xie, Yangbai Sun, Hanshao Liu, Yu Zhan, Yu Tao, Zhi Liu, Xiaohua Sun, Yiming Hu, Qi Wang, Deji Ye, Jie Zhang, Shanhua Zou, Ying Wang, Gang Wei, Yongzhong Liu, Yufang Shi, Y. Eugene Chin, Yongqiang Hao, Fudi Wang, Xiaoren Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-07-01 |
Deskripsi
The authors show an important role for iron in B cell proliferation via histone 3 lysine 9 (H3K9) demethylation at the cyclin E1 promoter. Using a measles vaccination murine model, they show that iron-deficient individuals have a significantly reduced antibody response to the vaccine when compared to iron-normal controls.